Assay Detail
Binding
CHEMBL677606
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In vitro inhibition constant of human leukocyte elastase.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,6-Disubstituted aryl carboxylic acids, leaving groups "par excellence" for benzisothiazolone inhibitors of human leukocyte elastase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 8.61 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL538776 | — | — | 1 | 11.00 |
| CHEMBL314218 | — | — | 1 | 10.52 |
| CHEMBL91944 | — | — | 1 | 10.22 |
| CHEMBL432049 | — | — | 1 | 9.77 |
| CHEMBL421162 | — | — | 1 | 9.00 |
| CHEMBL90327 | — | — | 1 | 8.70 |
| CHEMBL274085 | — | — | 1 | 8.57 |
| CHEMBL89549 | — | — | 1 | 8.40 |
| CHEMBL88117 | — | — | 1 | 8.10 |
| CHEMBL89299 | — | — | 1 | 8.10 |
| CHEMBL88975 | — | — | 1 | 8.07 |
| CHEMBL86364 | — | — | 1 | 7.75 |
| CHEMBL90730 | — | — | 1 | 7.58 |
| CHEMBL329376 | — | — | 1 | 7.51 |
| CHEMBL85128 | — | — | 1 | 7.43 |
| CHEMBL51377 | — | — | 1 | 6.99 |
| CHEMBL553298 | — | — | 1 | - |
| CHEMBL539031 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL538776 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL314218 | — | Ki | = | 0.03 | nM | 10.52 |
| CHEMBL91944 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL432049 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL421162 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL90327 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL274085 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL89549 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL88117 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL89299 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL88975 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL86364 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL90730 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL329376 | — | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL85128 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL51377 | — | Ki | = | 102.0 | nM | 6.99 |
| CHEMBL553298 | — | Ki | = | 0.007 | nM | - |
| CHEMBL539031 | — | Ki | = | 0.008 | nM | - |