Assay Detail
Binding
CHEMBL677607
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition constant (Ki) against human leukocyte elastase (HLE-catalyzed hydrolysis of MeO-Suc-Ala-Ala-Pro-Ala-pNA)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Nonpeptidic inhibitors of human leukocyte elastase. 6. Design of a potent, intratracheally active, pyridone-based trifluoromethyl ketone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.99 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307315 | — | — | 1 | 9.15 |
| CHEMBL55210 | — | — | 1 | 8.72 |
| CHEMBL304354 | — | — | 1 | 8.22 |
| CHEMBL66579 | — | — | 1 | 8.10 |
| CHEMBL303165 | — | — | 1 | 8.08 |
| CHEMBL303493 | — | — | 1 | 8.03 |
| CHEMBL308881 | — | — | 1 | 7.75 |
| CHEMBL66520 | — | — | 1 | 7.58 |
| CHEMBL68841 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307315 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL55210 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL304354 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL66579 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL303165 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL303493 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL308881 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL66520 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL68841 | — | Ki | = | 480.0 | nM | 6.32 |