Assay Detail
Binding
CHEMBL677791
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Ro- 15-4513 from alpha-1-beta-2-gamma-2 GABA-A receptor subunits expressed in Sf9 cell membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antagonist, partial agonist, and full agonist imidazo[1,5-a]quinoxaline amides and carbamates acting through the GABAA/benzodiazepine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.83 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164243 | — | — | 1 | 7.88 |
| CHEMBL165458 | — | — | 1 | 7.09 |
| CHEMBL352676 | — | — | 1 | 6.97 |
| CHEMBL299133 | — | — | 1 | 6.91 |
| CHEMBL354385 | — | — | 1 | 6.17 |
| CHEMBL49888 | — | — | 1 | 5.94 |
| CHEMBL351822 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164243 | — | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL165458 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL352676 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL299133 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL354385 | — | Ki | = | 681.0 | nM | 6.17 |
| CHEMBL49888 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL351822 | — | Ki | > | 10000.0 | nM | - |