Assay Detail
Binding
CHEMBL677849
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Inhibition of [3H]FPP incorporation into recombinant human K-Ras by Farnesyltransferase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.65 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125162 | — | — | 1 | 9.96 |
| CHEMBL125558 | — | — | 1 | 9.74 |
| CHEMBL125648 | — | — | 1 | 9.36 |
| CHEMBL333317 | — | — | 1 | 8.05 |
| CHEMBL331496 | — | — | 1 | 7.68 |
| CHEMBL125129 | — | — | 1 | 7.10 |
| CHEMBL124576 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125162 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL125558 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL125648 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL333317 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL331496 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL125129 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL124576 | — | IC50 | > | 0.15 | nM | - |