Assay Detail
Binding
CHEMBL678075
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Inhibitory concentration against recombinant human Endothelial nitric oxide synthase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dihydroquinolines with amine-containing side chains as potent n-NOS inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.39 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL227744 | NITROARGININE | 1.0 | 1 | 6.50 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 6.27 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 5.82 |
| CHEMBL61969 | — | — | 1 | 5.48 |
| CHEMBL293212 | — | — | 1 | 5.46 |
| CHEMBL292099 | — | — | 1 | 5.21 |
| CHEMBL542132 | — | — | 1 | 5.17 |
| CHEMBL552822 | — | — | 1 | 5.06 |
| CHEMBL545441 | — | — | 1 | 5.03 |
| CHEMBL544514 | — | — | 1 | 5.02 |
| CHEMBL538997 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL227744 | NITROARGININE | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL256147 | TILARGININE | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL7890 | L-NAME | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL61969 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL293212 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL292099 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL542132 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL552822 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL545441 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL544514 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL538997 | — | IC50 | = | 52000.0 | nM | 4.28 |