Assay Detail
Binding
CHEMBL678078
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inhibition of human endothelial constitutive Endothelial nitric oxide synthase (heNOS)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.33 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269076 | — | — | 1 | 6.52 |
| CHEMBL265672 | — | — | 1 | 6.22 |
| CHEMBL6808 | — | — | 1 | 5.96 |
| CHEMBL267038 | — | — | 1 | 5.70 |
| CHEMBL6760 | — | — | 1 | 5.66 |
| CHEMBL267167 | — | — | 1 | 5.52 |
| CHEMBL269058 | — | — | 1 | 5.33 |
| CHEMBL6643 | — | — | 1 | 5.28 |
| CHEMBL6813 | — | — | 1 | 4.89 |
| CHEMBL6875 | — | — | 1 | 4.36 |
| CHEMBL268312 | — | — | 1 | 4.33 |
| CHEMBL269330 | — | — | 1 | 4.24 |
| CHEMBL7133 | — | — | 1 | - |
| CHEMBL6656 | — | — | 1 | - |
| CHEMBL6657 | — | — | 1 | - |
| CHEMBL268294 | — | — | 1 | - |
| CHEMBL266980 | — | — | 1 | - |
| CHEMBL269560 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269076 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL265672 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL6808 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL267038 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL6760 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL267167 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL269058 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL6643 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL6813 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL6875 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL268312 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL269330 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL7133 | — | IC50 | = | 142000.0 | nM | - |
| CHEMBL6656 | — | IC50 | = | 218000.0 | nM | - |
| CHEMBL6657 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL268294 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL266980 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL269560 | — | IC50 | = | 375000.0 | nM | - |