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Assay Detail

CHEMBL678114

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Binding
Inhibitory activity against endothelial nitric oxide synthase (eNOS)
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Nitric oxide synthase 3 (CHEMBL4802)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Aromatic reduced amide bond peptidomimetics as selective inhibitors of neuronal nitric oxide synthase.
Hah JM, Martásek P, Roman LJ, Silverman RB.
J Med Chem (2003) 46 : 1661 -1669
PubMed 12699384 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 4.39 5.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL297096 1 5.30
CHEMBL442999 1 4.52
CHEMBL297207 1 4.40
CHEMBL296102 1 4.32
CHEMBL297095 1 4.11
CHEMBL42093 1 4.07
CHEMBL45132 1 4.00
CHEMBL295848 1 -
CHEMBL227937 1 -
CHEMBL43997 1 -
CHEMBL45119 1 -
CHEMBL46974 1 -
CHEMBL45243 1 -
CHEMBL43937 1 -
CHEMBL45021 1 -
CHEMBL44964 1 -
CHEMBL45441 1 -
CHEMBL433260 1 -
CHEMBL46913 1 -
CHEMBL297372 1 -
CHEMBL45113 1 -
CHEMBL48070 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL297096 Ki = 5000.0 nM 5.30
CHEMBL442999 Ki = 30100.0 nM 4.52
CHEMBL297207 Ki = 39800.0 nM 4.40
CHEMBL296102 Ki = 47600.0 nM 4.32
CHEMBL297095 Ki = 78600.0 nM 4.11
CHEMBL42093 Ki = 86100.0 nM 4.07
CHEMBL45132 Ki = 100000.0 nM 4.00
CHEMBL295848 Ki = 123000.0 nM -
CHEMBL227937 Ki = 314000.0 nM -
CHEMBL43997 Ki = 116000.0 nM -
CHEMBL45119 Ki = 443000.0 nM -
CHEMBL46974 Ki = 589000.0 nM -
CHEMBL45243 Ki = 193000.0 nM -
CHEMBL43937 Ki = 523000.0 nM -
CHEMBL45021 Ki = 185000.0 nM -
CHEMBL44964 Ki = 303000.0 nM -
CHEMBL45441 Ki = 275000.0 nM -
CHEMBL433260 Ki = 194000.0 nM -
CHEMBL46913 Ki = 409000.0 nM -
CHEMBL297372 Ki = 105000.0 nM -
CHEMBL45113 Ki = 414000.0 nM -
CHEMBL48070 Ki = 170000.0 nM -