Assay Detail
Binding
CHEMBL678142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for binding affinity against human FK506 binding protein 12
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase FKBP1A (CHEMBL1902) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Retention of immunosuppressant activity in an ascomycin analogue lacking a hydrogen-bonding interaction with FKBP12.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.18 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71458 | — | — | 1 | 9.11 |
| CHEMBL8597 | ASCOMYCIN | — | 1 | 8.68 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 8.64 |
| CHEMBL139966 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71458 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL8597 | ASCOMYCIN | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL139966 | — | IC50 | = | 529.0 | nM | 6.28 |