Assay Detail
Binding
CHEMBL678143
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Compound was tested for its ability to inhibit FK506 binding protein 12 rotamase activity
67
Total Activities
67
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Peptidyl-prolyl cis-trans isomerase FKBP1A (CHEMBL1902) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Immunophilins: beyond immunosuppression.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 67 | 7.28 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 9.70 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | 4.0 | 1 | 9.40 |
| CHEMBL151727 | — | — | 1 | 9.30 |
| CHEMBL2052020 | — | — | 1 | 9.15 |
| CHEMBL54189 | — | — | 1 | 9.00 |
| CHEMBL151841 | — | — | 1 | 9.00 |
| CHEMBL50795 | — | — | 1 | 8.70 |
| CHEMBL150120 | — | — | 1 | 8.52 |
| CHEMBL300752 | — | — | 1 | 8.52 |
| CHEMBL423033 | — | — | 1 | 8.52 |
| CHEMBL417192 | — | — | 1 | 8.30 |
| CHEMBL149192 | — | — | 1 | 8.12 |
| CHEMBL300040 | — | — | 1 | 8.08 |
| CHEMBL148517 | — | — | 1 | 8.05 |
| CHEMBL342735 | — | — | 1 | 7.92 |
| CHEMBL265972 | — | — | 1 | 7.92 |
| CHEMBL150100 | — | — | 1 | 7.89 |
| CHEMBL146919 | — | — | 1 | 7.82 |
| CHEMBL148446 | — | — | 1 | 7.77 |
| CHEMBL148435 | — | — | 1 | 7.77 |
| CHEMBL150062 | — | — | 1 | 7.75 |
| CHEMBL417908 | — | — | 1 | 7.70 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 7.70 |
| CHEMBL51710 | — | — | 1 | 7.62 |
| CHEMBL299152 | — | — | 1 | 7.60 |
| CHEMBL298173 | — | — | 1 | 7.52 |
| CHEMBL149707 | — | — | 1 | 7.50 |
| CHEMBL148494 | — | — | 1 | 7.47 |
| CHEMBL148982 | — | — | 1 | 7.40 |
| CHEMBL149314 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL269732 | TACROLIMUS ANHYDROUS | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL151727 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL2052020 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL54189 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL151841 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL50795 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL150120 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL300752 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL423033 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL417192 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL149192 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL300040 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL148517 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL265972 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL342735 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL150100 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL146919 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL148446 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL148435 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL150062 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL417908 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL160 | CYCLOSPORINE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL51710 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL299152 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL298173 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL149707 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL148494 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL148982 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL149314 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL2371001 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL357727 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL52541 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL343212 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL150229 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL151327 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL149373 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL148516 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL146203 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL346171 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL149669 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL341856 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL108247 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL148621 | — | Ki | = | 131.0 | nM | 6.88 |
| CHEMBL147712 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL107698 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL435686 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL151517 | — | Ki | = | 194.0 | nM | 6.71 |
| CHEMBL146204 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL357415 | — | Ki | = | 250.0 | nM | 6.60 |