Assay Detail
Binding
CHEMBL678150
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Ability to bind the major cystolic receptor FK506 binding protein 12 by using competitive binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase FKBP1A (CHEMBL1902) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Alkyl ether analogs of the FK-506 related, immunosuppressive macrolide L-683,590 (ascomycin)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.90 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8597 | ASCOMYCIN | — | 1 | 8.80 |
| CHEMBL384325 | — | — | 1 | 7.69 |
| CHEMBL262492 | — | — | 1 | 7.64 |
| CHEMBL406510 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8597 | ASCOMYCIN | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL384325 | — | EC50 | = | 20.5 | nM | 7.69 |
| CHEMBL262492 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL406510 | — | EC50 | = | 34.3 | nM | 7.46 |