Assay Detail
Functional
CHEMBL678236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity by measuring the [3H]thymidine uptake against Dopamine receptor D3 from rat
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-tetrahydro-4-n-propyl-2H,5H [1]b enzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 8.11 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240773 | QUINPIROLE | 2.0 | 1 | 8.77 |
| CHEMBL98836 | — | — | 1 | 7.44 |
| CHEMBL98305 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240773 | QUINPIROLE | EC50 | = | 1.7 | nM | 8.77 |
| CHEMBL98836 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL98305 | — | EC50 | = | 0.007 | nM | - |