Assay Detail
Binding
CHEMBL678240
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of compound required to inhibit the binding of radioligand [3H](R)-7-OH-DPAT to Dopamine receptor D3 in rat striatum
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1,4-diazepin-6-yl)pyridine-3-carboxamides with potent serotonin 5-HT3 and dopamine D2 receptor antagonistic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.14 | 8.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416047 | — | — | 1 | 8.95 |
| CHEMBL219916 | DOMPERIDONE | 3.0 | 1 | 8.57 |
| CHEMBL40497 | — | — | 1 | 7.84 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416047 | — | IC50 | = | 1.13 | nM | 8.95 |
| CHEMBL219916 | DOMPERIDONE | IC50 | = | 2.68 | nM | 8.57 |
| CHEMBL40497 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | = | 61.3 | nM | 7.21 |