Assay Detail
Binding
CHEMBL678318
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Inhibitory concentration towards rat mitochondrial F1F0 ATP hydrolase using a pyruvate kinase / lactate dehydrogenase system
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
Mitochondrial complex V; ATP synthase (CHEMBL612444) ↗| Type | PROTEIN COMPLEX |
| Organism | Bos taurus |
Publication
Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.79 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11859 | — | — | 1 | 6.62 |
| CHEMBL11502 | — | — | 1 | 6.32 |
| CHEMBL11594 | BMS-191095 | — | 1 | 6.32 |
| CHEMBL273271 | — | — | 1 | 5.85 |
| CHEMBL428891 | — | — | 1 | 5.70 |
| CHEMBL273900 | — | — | 1 | 5.38 |
| CHEMBL274443 | — | — | 1 | 4.35 |
| CHEMBL429014 | — | — | 1 | - |
| CHEMBL11802 | — | — | 1 | - |
| CHEMBL268271 | — | — | 1 | - |
| CHEMBL11458 | — | — | 1 | - |
| CHEMBL11392 | — | — | 1 | - |
| CHEMBL472 | GLYBURIDE | 4.0 | 1 | - |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | - |
| CHEMBL11183 | — | — | 1 | - |
| CHEMBL2052011 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11859 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL11502 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL11594 | BMS-191095 | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL273271 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL428891 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL273900 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL274443 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL429014 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL11802 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL268271 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL11458 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL11392 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL472 | GLYBURIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL49035 | CROMAKALIM | IC50 | > | 100000.0 | nM | - |
| CHEMBL11183 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2052011 | — | IC50 | = | 470000.0 | nM | - |