Assay Detail
Binding
CHEMBL678343
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity against recombinant dopamine receptor (DA) D2 expressed in CHO-K1 cells, using [3H]-spiperone as radioligand
48
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Substituted (S)-phenylpiperidines and rigid congeners as preferential dopamine autoreceptor antagonists: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 48 | 7.02 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7549 | PRECLAMOL | 2.0 | 1 | 7.41 |
| CHEMBL90359 | — | — | 1 | 7.32 |
| CHEMBL94811 | — | — | 1 | 7.22 |
| CHEMBL328119 | — | — | 1 | 7.14 |
| CHEMBL329443 | — | — | 1 | 7.04 |
| CHEMBL413483 | — | — | 1 | 7.01 |
| CHEMBL93570 | — | — | 1 | 6.87 |
| CHEMBL92578 | — | — | 1 | 6.84 |
| CHEMBL92817 | — | — | 1 | 6.77 |
| CHEMBL92183 | — | — | 1 | 6.58 |
| CHEMBL93646 | — | — | 1 | - |
| CHEMBL93283 | — | — | 1 | - |
| CHEMBL94224 | — | — | 1 | - |
| CHEMBL92232 | — | — | 1 | - |
| CHEMBL93946 | — | — | 1 | - |
| CHEMBL90797 | — | — | 1 | - |
| CHEMBL93701 | — | — | 1 | - |
| CHEMBL315890 | — | — | 1 | - |
| CHEMBL93254 | — | — | 1 | - |
| CHEMBL311730 | — | — | 1 | - |
| CHEMBL327263 | — | — | 1 | - |
| CHEMBL93594 | — | — | 1 | - |
| CHEMBL329139 | — | — | 1 | - |
| CHEMBL90662 | — | — | 1 | - |
| CHEMBL328431 | — | — | 1 | - |
| CHEMBL93212 | — | — | 1 | - |
| CHEMBL93682 | — | — | 1 | - |
| CHEMBL92630 | — | — | 1 | - |
| CHEMBL2111566 | — | — | 2 | - |
| CHEMBL93582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7549 | PRECLAMOL | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL90359 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL94811 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL328119 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL329443 | — | Ki | = | 91.0 | nM | 7.04 |
| CHEMBL413483 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL93570 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL92578 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL92817 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL92183 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL93900 | — | Ki | > | 217.0 | nM | - |
| CHEMBL90798 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93917 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93679 | — | Ki | > | 217.0 | nM | - |
| CHEMBL96726 | — | Ki | > | 217.0 | nM | - |
| CHEMBL328894 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93534 | — | Ki | > | 217.0 | nM | - |
| CHEMBL311730 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93234 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93254 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93101 | — | Ki | > | 217.0 | nM | - |
| CHEMBL328785 | — | Ki | > | 217.0 | nM | - |
| CHEMBL92938 | — | Ki | > | 217.0 | nM | - |
| CHEMBL96191 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93383 | — | Ki | > | 217.0 | nM | - |
| CHEMBL314536 | — | Ki | > | 217.0 | nM | - |
| CHEMBL91228 | — | Ki | > | 217.0 | nM | - |
| CHEMBL328448 | — | Ki | > | 217.0 | nM | - |
| CHEMBL92682 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93646 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93682 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93212 | — | Ki | > | 217.0 | nM | - |
| CHEMBL328431 | — | Ki | > | 217.0 | nM | - |
| CHEMBL90662 | — | Ki | > | 217.0 | nM | - |
| CHEMBL329139 | — | Ki | > | 217.0 | nM | - |
| CHEMBL94224 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93594 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93582 | — | Ki | > | 217.0 | nM | - |
| CHEMBL327263 | — | Ki | > | 217.0 | nM | - |
| CHEMBL315890 | — | Ki | > | 217.0 | nM | - |
| CHEMBL92232 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93946 | — | Ki | > | 217.0 | nM | - |
| CHEMBL90797 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93701 | — | Ki | > | 217.0 | nM | - |
| CHEMBL2111566 | — | Ki | > | 217.0 | nM | - |
| CHEMBL2111566 | — | Ki | > | 217.0 | nM | - |
| CHEMBL93283 | — | Ki | > | 217.0 | nM | - |
| CHEMBL92630 | — | Ki | > | 217.0 | nM | - |