Assay Detail
Binding
CHEMBL678455
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Binding affinity for human endothelin B receptor expressed in CHO-K1 cells.
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
-Carbamate butenolide analogues as potent ETA selective endothelin receptor antagonists and prodrugs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.78 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8981 | PD-156707 | — | 1 | 6.32 |
| CHEMBL103846 | — | — | 1 | 5.89 |
| CHEMBL319452 | — | — | 1 | 5.75 |
| CHEMBL316523 | — | — | 1 | 5.60 |
| CHEMBL51530 | — | — | 1 | 5.34 |
| CHEMBL320839 | — | — | 1 | - |
| CHEMBL276173 | — | — | 1 | - |
| CHEMBL450337 | — | — | 1 | - |
| CHEMBL322920 | — | — | 3 | - |
| CHEMBL103501 | — | — | 1 | - |
| CHEMBL320183 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8981 | PD-156707 | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL103846 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL319452 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL316523 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL51530 | — | IC50 | = | 4550.0 | nM | 5.34 |
| CHEMBL320839 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL276173 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL450337 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL322920 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL103501 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL322920 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL320183 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL322920 | — | IC50 | > | 2500.0 | nM | - |