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Assay Detail

CHEMBL678694

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Binding
Dissociation constant for Fibroblast growth factor 2
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Fibroblast growth factor 2 (CHEMBL3107)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Validation of molecular docking calculations involving FGF-1 and FGF-2.
Bytheway I, Cochran S.
J Med Chem (2004) 47 : 1683 -1693
PubMed 15027859 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 17 5.11 5.93

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2303816 1 5.93
CHEMBL3144211 1 5.26
CHEMBL2093120 1 5.20
CHEMBL2029141 1 4.88
CHEMBL2303818 1 4.79
CHEMBL2303817 1 4.57
CHEMBL1160124 1 -
CHEMBL1160119 1 -
CHEMBL1160112 1 -
CHEMBL1160111 1 -
CHEMBL1160123 1 -
CHEMBL2029142 1 -
CHEMBL1160117 NAPHTHALENE TRISULFONATE 1 -
CHEMBL2303821 1 -
CHEMBL1160122 1 -
CHEMBL2303819 1 -
CHEMBL1160126 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2303816 Kd = 1180.0 nM 5.93
CHEMBL3144211 Kd = 5500.0 nM 5.26
CHEMBL2093120 Kd = 6300.0 nM 5.20
CHEMBL2029141 Kd = 13300.0 nM 4.88
CHEMBL2303818 Kd = 16200.0 nM 4.79
CHEMBL2303817 Kd = 26700.0 nM 4.57
CHEMBL1160124 Kd = 258000.0 nM -
CHEMBL1160119 Kd = 249000.0 nM -
CHEMBL1160112 Kd = 5100000.0 nM -
CHEMBL1160111 Kd = 7500000.0 nM -
CHEMBL1160123 Kd = 17400000.0 nM -
CHEMBL2029142 Kd = 343000.0 nM -
CHEMBL1160117 NAPHTHALENE TRISULFONATE Kd = 223000.0 nM -
CHEMBL2303821 Kd = 550000.0 nM -
CHEMBL1160122 Kd = 8020000.0 nM -
CHEMBL2303819 Kd = 155000.0 nM -
CHEMBL1160126 Kd = 375000.0 nM -