Assay Detail
Functional
CHEMBL678730
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity against isolated frog rectus abdominus muscle (FRA)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | frog |
| Tissue | Muscle tissue |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.58 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553023 | — | — | 1 | 6.69 |
| CHEMBL342756 | — | — | 1 | 6.39 |
| CHEMBL542756 | — | — | 1 | 6.35 |
| CHEMBL553264 | — | — | 1 | 6.23 |
| CHEMBL540608 | — | — | 1 | 6.10 |
| CHEMBL554889 | — | — | 1 | 5.96 |
| CHEMBL1256938 | — | — | 1 | 5.93 |
| CHEMBL556027 | — | — | 1 | 5.90 |
| CHEMBL1161299 | — | — | 1 | 5.82 |
| CHEMBL542512 | — | — | 1 | 5.79 |
| CHEMBL543452 | — | — | 1 | 5.75 |
| CHEMBL557429 | — | — | 1 | 5.64 |
| CHEMBL542982 | — | — | 1 | 5.61 |
| CHEMBL538292 | — | — | 1 | 5.60 |
| CHEMBL1161309 | — | — | 1 | 5.28 |
| CHEMBL552809 | — | — | 1 | 5.27 |
| CHEMBL543931 | — | — | 1 | 5.27 |
| CHEMBL557224 | — | — | 1 | 5.22 |
| CHEMBL542504 | — | — | 1 | 5.19 |
| CHEMBL552626 | — | — | 1 | 5.14 |
| CHEMBL147338 | — | — | 1 | 4.92 |
| CHEMBL542507 | — | — | 1 | 4.64 |
| CHEMBL555772 | — | — | 1 | 4.62 |
| CHEMBL542509 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553023 | — | IC50 | = | 204.17 | nM | 6.69 |
| CHEMBL342756 | — | IC50 | = | 407.38 | nM | 6.39 |
| CHEMBL542756 | — | IC50 | = | 446.68 | nM | 6.35 |
| CHEMBL553264 | — | IC50 | = | 588.84 | nM | 6.23 |
| CHEMBL540608 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL554889 | — | IC50 | = | 1096.48 | nM | 5.96 |
| CHEMBL1256938 | — | IC50 | = | 1174.9 | nM | 5.93 |
| CHEMBL556027 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL1161299 | — | IC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL542512 | — | IC50 | = | 1621.81 | nM | 5.79 |
| CHEMBL543452 | — | IC50 | = | 1778.28 | nM | 5.75 |
| CHEMBL557429 | — | IC50 | = | 2290.87 | nM | 5.64 |
| CHEMBL542982 | — | IC50 | = | 2454.71 | nM | 5.61 |
| CHEMBL538292 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL1161309 | — | IC50 | = | 5248.07 | nM | 5.28 |
| CHEMBL552809 | — | IC50 | = | 5370.32 | nM | 5.27 |
| CHEMBL543931 | — | IC50 | = | 5370.32 | nM | 5.27 |
| CHEMBL557224 | — | IC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL542504 | — | IC50 | = | 6456.54 | nM | 5.19 |
| CHEMBL552626 | — | IC50 | = | 7244.36 | nM | 5.14 |
| CHEMBL147338 | — | IC50 | = | 12022.64 | nM | 4.92 |
| CHEMBL542507 | — | IC50 | = | 22908.68 | nM | 4.64 |
| CHEMBL555772 | — | IC50 | = | 23988.33 | nM | 4.62 |
| CHEMBL542509 | — | IC50 | = | 25118.86 | nM | 4.60 |