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Assay Detail

CHEMBL678772

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration of compound against Epstein Barr virus was determined
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human gammaherpesvirus 4
Confidence 1 — Organism
Curated By Intermediate

Target

Human gammaherpesvirus 4 (CHEMBL613124)
Type ORGANISM
Organism Human gammaherpesvirus 4

Publication

Structure-activity relationships of L-dioxolane uracil nucleosides as anti-Epstein Barr virus agents.
Lin JS, Kira T, Gullen E, Choi Y, Qu F, Chu CK, Cheng YC.
J Med Chem (1999) 42 : 2212 -2217
PubMed 10377226 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 5.50 7.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL46089 2 7.48
CHEMBL303553 1 6.72
CHEMBL45897 1 6.55
CHEMBL49561 1 5.40
CHEMBL3142241 1 5.30
CHEMBL182 GANCICLOVIR 4.0 1 4.30
CHEMBL70421 1 4.30
CHEMBL61323 1 4.30
CHEMBL292278 1 -
CHEMBL70938 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL46089 EC50 = 33.0 nM 7.48
CHEMBL303553 EC50 = 190.0 nM 6.72
CHEMBL45897 EC50 = 280.0 nM 6.55
CHEMBL49561 EC50 = 4000.0 nM 5.40
CHEMBL3142241 EC50 = 5000.0 nM 5.30
CHEMBL46089 EC50 = 7600.0 nM 5.12
CHEMBL182 GANCICLOVIR EC50 = 50000.0 nM 4.30
CHEMBL70421 EC50 = 50000.0 nM 4.30
CHEMBL61323 EC50 = 50000.0 nM 4.30
CHEMBL292278 EC50 > 50000.0 nM -
CHEMBL70938 EC50 > 100000.0 nM -