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Assay Detail

CHEMBL678775

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Functional
In vitro antimalarial activity against the Plasmodium falciparum FCR3
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Potent antimalarial febrifugine analogues against the plasmodium malaria parasite.
Kikuchi H, Tasaka H, Hirai S, Takaya Y, Iwabuchi Y, Ooi H, Hatakeyama S, Kim HS, Wataya Y, Oshima Y.
J Med Chem (2002) 45 : 2563 -2570
PubMed 12036365 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 28 6.87 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL110619 1 8.80
CHEMBL606775 1 8.72
CHEMBL107040 1 8.55
CHEMBL105789 ISOFEBRIFUGINE 1 8.47
CHEMBL606827 1 8.44
CHEMBL76 CHLOROQUINE 4.0 1 7.75
CHEMBL606715 1 7.72
CHEMBL87905 1 7.70
CHEMBL314435 1 7.43
CHEMBL86747 1 7.40
CHEMBL313594 1 7.32
CHEMBL606713 1 7.00
CHEMBL606648 1 6.52
CHEMBL606712 1 6.40
CHEMBL606773 1 6.40
CHEMBL606878 1 6.38
CHEMBL420238 1 6.30
CHEMBL420413 1 6.22
CHEMBL479432 FEBRIFUGINE 1 6.16
CHEMBL606714 1 6.10
CHEMBL606880 1 6.08
CHEMBL315920 1 6.08
CHEMBL87920 1 6.04
CHEMBL315061 1 5.68
CHEMBL606774 1 5.47
CHEMBL606879 1 5.32
CHEMBL606772 1 5.16
CHEMBL313964 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL110619 EC50 = 1.6 nM 8.80
CHEMBL606775 EC50 = 1.9 nM 8.72
CHEMBL107040 EC50 = 2.8 nM 8.55
CHEMBL105789 ISOFEBRIFUGINE EC50 = 3.4 nM 8.47
CHEMBL606827 EC50 = 3.6 nM 8.44
CHEMBL76 CHLOROQUINE EC50 = 18.0 nM 7.75
CHEMBL606715 EC50 = 19.0 nM 7.72
CHEMBL87905 EC50 = 20.0 nM 7.70
CHEMBL314435 EC50 = 37.0 nM 7.43
CHEMBL86747 EC50 = 40.0 nM 7.40
CHEMBL313594 EC50 = 48.0 nM 7.32
CHEMBL606713 EC50 = 100.0 nM 7.00
CHEMBL606648 EC50 = 300.0 nM 6.52
CHEMBL606712 EC50 = 400.0 nM 6.40
CHEMBL606773 EC50 = 400.0 nM 6.40
CHEMBL606878 EC50 = 420.0 nM 6.38
CHEMBL420238 EC50 = 500.0 nM 6.30
CHEMBL420413 EC50 = 600.0 nM 6.22
CHEMBL479432 FEBRIFUGINE EC50 = 700.0 nM 6.16
CHEMBL606714 EC50 = 800.0 nM 6.10
CHEMBL606880 EC50 = 830.0 nM 6.08
CHEMBL315920 EC50 = 840.0 nM 6.08
CHEMBL87920 EC50 = 910.0 nM 6.04
CHEMBL315061 EC50 = 2100.0 nM 5.68
CHEMBL606774 EC50 = 3400.0 nM 5.47
CHEMBL606879 EC50 = 4800.0 nM 5.32
CHEMBL606772 EC50 = 7000.0 nM 5.16
CHEMBL313964 EC50 = - nM -