Assay Detail
Binding
CHEMBL678783
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compound was tested for the ability to function as transport substrates for the human folate-binding protein(mFBP)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Protein structure-based design, synthesis, and biological evaluation of 5-thia-2,6-diamino-4(3H)-oxopyrimidines: potent inhibitors of glycinamide ribonucleotide transformylase with potent cell growth inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 8.66 | 9.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85871 | — | — | 1 | 9.81 |
| CHEMBL84935 | — | — | 1 | 9.42 |
| CHEMBL309415 | — | — | 1 | 9.24 |
| CHEMBL82390 | — | — | 1 | 9.16 |
| CHEMBL82261 | — | — | 1 | 9.02 |
| CHEMBL85848 | — | — | 1 | 7.08 |
| CHEMBL315627 | — | — | 1 | 6.87 |
| CHEMBL84163 | — | — | 1 | - |
| CHEMBL85436 | — | — | 1 | - |
| CHEMBL315076 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85871 | — | Kd | = | 0.153 | nM | 9.81 |
| CHEMBL84935 | — | Kd | = | 0.38 | nM | 9.42 |
| CHEMBL309415 | — | Kd | = | 0.57 | nM | 9.24 |
| CHEMBL82390 | — | Kd | = | 0.69 | nM | 9.16 |
| CHEMBL82261 | — | Kd | = | 0.95 | nM | 9.02 |
| CHEMBL85848 | — | Kd | = | 83.0 | nM | 7.08 |
| CHEMBL315627 | — | Kd | = | 136.0 | nM | 6.87 |
| CHEMBL84163 | — | Kd | = | 0.0032 | nM | - |
| CHEMBL85436 | — | Kd | = | 0.0005 | nM | - |
| CHEMBL315076 | — | Kd | = | 0.002 | nM | - |