Assay Detail
Binding
CHEMBL678806
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GAR transformylase in hog liver
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Liver |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Trifunctional purine biosynthetic protein adenosine-3 (CHEMBL3972) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.22 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170101 | — | — | 1 | 6.66 |
| CHEMBL13659 | — | — | 1 | 5.52 |
| CHEMBL157230 | — | — | 1 | 5.28 |
| CHEMBL156308 | — | — | 1 | 4.58 |
| CHEMBL157857 | — | — | 1 | 4.07 |
| CHEMBL156551 | — | — | 1 | - |
| CHEMBL157775 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170101 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL13659 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL157230 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL156308 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL157857 | — | IC50 | = | 85900.0 | nM | 4.07 |
| CHEMBL156551 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL157775 | — | IC50 | > | 100000.0 | nM | - |