Assay Detail
Binding
CHEMBL678807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of hog liver GAR transformylase with (6R)-10-formyl-FH4 as cofactor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Trifunctional purine biosynthetic protein adenosine-3 (CHEMBL3972) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.33 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170101 | — | — | 1 | 6.66 |
| CHEMBL13705 | DIDEAZAACYCLOTETRAHYDROFOLIC ACID | — | 1 | 5.80 |
| CHEMBL30842 | — | — | 1 | 5.58 |
| CHEMBL13659 | — | — | 1 | 5.52 |
| CHEMBL31176 | — | — | 1 | 5.51 |
| CHEMBL285232 | — | — | 1 | 5.46 |
| CHEMBL31609 | — | — | 1 | 5.28 |
| CHEMBL30301 | — | — | 1 | 5.21 |
| CHEMBL417304 | — | — | 1 | 5.18 |
| CHEMBL30364 | — | — | 1 | 4.74 |
| CHEMBL29713 | — | — | 1 | 4.73 |
| CHEMBL31027 | — | — | 1 | 4.28 |
| CHEMBL31107 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170101 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL13705 | DIDEAZAACYCLOTETRAHYDROFOLIC ACID | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL30842 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL13659 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL31176 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL285232 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL31609 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL30301 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL417304 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL30364 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL29713 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL31027 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL31107 | — | IC50 | > | 100000.0 | nM | - |