Assay Detail
Binding
CHEMBL678864
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]spiperone from human dopamine receptor D3 (hD3) receptor stably expressed in HEK293 cells.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-Heterocyclylpiperidines as selective high-affinity ligands at the human dopamine D4 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 6.23 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.70 |
| CHEMBL78933 | — | — | 1 | 7.34 |
| CHEMBL61195 | — | — | 1 | 7.10 |
| CHEMBL78923 | — | — | 1 | 6.85 |
| CHEMBL76090 | — | — | 1 | 6.80 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.70 |
| CHEMBL80833 | — | — | 1 | 6.62 |
| CHEMBL309901 | — | — | 1 | 6.37 |
| CHEMBL58296 | — | — | 1 | 6.37 |
| CHEMBL293341 | — | — | 1 | 6.32 |
| CHEMBL2112285 | — | — | 1 | 6.29 |
| CHEMBL2112284 | — | — | 1 | 6.29 |
| CHEMBL311832 | — | — | 1 | 6.22 |
| CHEMBL420954 | — | — | 1 | 6.14 |
| CHEMBL444309 | — | — | 1 | 6.11 |
| CHEMBL61080 | — | — | 1 | 6.09 |
| CHEMBL80318 | — | — | 1 | 6.08 |
| CHEMBL77017 | — | — | 1 | 6.06 |
| CHEMBL76355 | — | — | 1 | 6.04 |
| CHEMBL80722 | — | — | 1 | 5.96 |
| CHEMBL77743 | — | — | 1 | 5.96 |
| CHEMBL61079 | — | — | 1 | 5.92 |
| CHEMBL77744 | — | — | 1 | 5.92 |
| CHEMBL310985 | — | — | 1 | 5.92 |
| CHEMBL312255 | — | — | 1 | 5.89 |
| CHEMBL80207 | — | — | 1 | 5.89 |
| CHEMBL25938 | — | — | 1 | 5.85 |
| CHEMBL80863 | — | — | 1 | 5.75 |
| CHEMBL77148 | — | — | 1 | 5.68 |
| CHEMBL77015 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL78933 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL61195 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL78923 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL76090 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL42 | CLOZAPINE | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL80833 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL309901 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL58296 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL293341 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL2112285 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL2112284 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL311832 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL420954 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL444309 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL61080 | — | Ki | = | 820.0 | nM | 6.09 |
| CHEMBL80318 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL77017 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL76355 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL77743 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL80722 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL61079 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL77744 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL310985 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL312255 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL80207 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL25938 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL80863 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL77148 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL77015 | — | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL310819 | — | Ki | = | 3600.0 | nM | 5.44 |
| CHEMBL78287 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL80552 | — | Ki | > | 1900.0 | nM | - |
| CHEMBL79098 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL75691 | — | Ki | > | 4400.0 | nM | - |
| CHEMBL6416 | — | Ki | > | 4000.0 | nM | - |
| CHEMBL309460 | — | Ki | > | 4200.0 | nM | - |