Assay Detail
Functional
CHEMBL678866
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Rate of influx of compound into the Ehrlich cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Ehrlich |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.12 | 5.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | 2.0 | 1 | 5.69 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.00 |
| CHEMBL11187 | — | — | 1 | 4.91 |
| CHEMBL10592 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376180 | AMINOPTERIN | Ki | = | 2050.0 | nM | 5.69 |
| CHEMBL34259 | METHOTREXATE | Ki | = | 10100.0 | nM | 5.00 |
| CHEMBL11187 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL10592 | — | Ki | = | 12900.0 | nM | 4.89 |