Assay Detail
Binding
CHEMBL679022
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Inhibitory concentration against human estrogen receptor(ER) polymerase chain reaction product
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1, 4]benzodiazepine and minor-groove-binding oligopyrrole carriers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.94 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL552873 | — | — | 1 | 6.70 |
| CHEMBL554203 | — | — | 1 | 6.30 |
| CHEMBL554551 | — | — | 1 | 6.10 |
| CHEMBL553022 | — | — | 1 | 5.70 |
| CHEMBL554057 | — | — | 1 | 5.52 |
| CHEMBL3216873 | — | — | 1 | 5.30 |
| CHEMBL300580 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL552873 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL554203 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL554551 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL553022 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL554057 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3216873 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL300580 | — | IC50 | > | 250000.0 | nM | - |