Assay Detail
Functional
CHEMBL679216
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Inhibitory activity against F460pv8/eto cell line using MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | F460pv8/eto |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.51 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.70 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 7.40 |
| CHEMBL43453 | — | — | 1 | 7.00 |
| CHEMBL41700 | — | — | 1 | 6.92 |
| CHEMBL41526 | — | — | 1 | 6.47 |
| CHEMBL38451 | — | — | 1 | 6.31 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.13 |
| CHEMBL41174 | — | — | 1 | 5.97 |
| CHEMBL43229 | — | — | 1 | 5.96 |
| CHEMBL41863 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL43 | AMSACRINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL43453 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL41700 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL41526 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL38451 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL41174 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL43229 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL41863 | — | IC50 | = | 6470.0 | nM | 5.19 |