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Assay Detail

CHEMBL679229

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [125I]iodosulpiride from human Dopamine receptor D3 expressed in CHO cells
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type CHO
Confidence 8 — Homologous single protein target
Curated By Expert

Target

D(3) dopamine receptor (CHEMBL234)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel 1,2,3,4-tetrahydroisoquinolines with high affinity and selectivity for the dopamine D3 receptor.
Austin NE, Avenell KY, Boyfield I, Branch CL, Coldwell MC, Hadley MS, Jeffrey P, Johns A, Johnson CN, Nash DJ, Riley GJ, Smith SA, Stacey RC, Stemp G, Thewlis KM, Vong AK.
Bioorg Med Chem Lett (1999) 9 : 179 -184
PubMed 10021923 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 27 8.26 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL57219 1 8.80
CHEMBL51977 1 8.80
CHEMBL291545 1 8.70
CHEMBL52724 1 8.70
CHEMBL279925 1 8.70
CHEMBL52466 1 8.60
CHEMBL297960 1 8.60
CHEMBL54777 1 8.60
CHEMBL367129 1 8.60
CHEMBL52468 1 8.50
CHEMBL416842 1 8.50
CHEMBL293347 1 8.40
CHEMBL301475 1 8.40
CHEMBL52987 1 8.40
CHEMBL52901 1 8.40
CHEMBL52135 1 8.40
CHEMBL53351 1 8.40
CHEMBL55090 1 8.40
CHEMBL55276 1 8.30
CHEMBL55840 1 8.30
CHEMBL299038 1 8.10
CHEMBL292577 1 8.00
CHEMBL53833 1 7.60
CHEMBL55524 1 7.40
CHEMBL54715 1 7.30
CHEMBL54948 1 7.30
CHEMBL52770 1 6.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL57219 Ki = 1.585 nM 8.80
CHEMBL51977 Ki = 1.585 nM 8.80
CHEMBL291545 Ki = 1.995 nM 8.70
CHEMBL52724 Ki = 1.995 nM 8.70
CHEMBL279925 Ki = 1.995 nM 8.70
CHEMBL52466 Ki = 2.512 nM 8.60
CHEMBL297960 Ki = 2.512 nM 8.60
CHEMBL54777 Ki = 2.512 nM 8.60
CHEMBL367129 Ki = 2.512 nM 8.60
CHEMBL52468 Ki = 3.162 nM 8.50
CHEMBL416842 Ki = 3.162 nM 8.50
CHEMBL293347 Ki = 3.981 nM 8.40
CHEMBL301475 Ki = 3.981 nM 8.40
CHEMBL52987 Ki = 3.981 nM 8.40
CHEMBL52901 Ki = 3.981 nM 8.40
CHEMBL52135 Ki = 3.981 nM 8.40
CHEMBL53351 Ki = 3.981 nM 8.40
CHEMBL55090 Ki = 3.981 nM 8.40
CHEMBL55276 Ki = 5.012 nM 8.30
CHEMBL55840 Ki = 5.012 nM 8.30
CHEMBL299038 Ki = 7.943 nM 8.10
CHEMBL292577 Ki = 10.0 nM 8.00
CHEMBL53833 Ki = 25.12 nM 7.60
CHEMBL55524 Ki = 39.81 nM 7.40
CHEMBL54715 Ki = 50.12 nM 7.30
CHEMBL54948 Ki = 50.12 nM 7.30
CHEMBL52770 Ki = 125.89 nM 6.90