Assay Detail
Functional
CHEMBL679255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Feline immunodeficiency virus (FIV) protease
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Feline immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Feline immunodeficiency virus (CHEMBL613744) ↗| Type | ORGANISM |
| Organism | Feline immunodeficiency virus |
Publication
Design, synthesis, and biological evaluation of HIV/FIV protease inhibitors incorporating a conformationally constrained macrocycle with a small P3' residue.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.26 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74166 | — | — | 1 | 7.57 |
| CHEMBL70388 | — | — | 1 | 7.46 |
| CHEMBL302958 | — | — | 1 | 7.31 |
| CHEMBL305458 | — | — | 1 | 7.14 |
| CHEMBL72129 | — | — | 1 | 6.83 |
| CHEMBL71961 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74166 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL70388 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL302958 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL305458 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL72129 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL71961 | — | IC50 | 95.0 | nM | - |