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Assay Detail

CHEMBL679288

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Binding
Inhibitory activity against endothelial nitric oxide synthase (eNOS)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Computer modeling of selective regions in the active site of nitric oxide synthases: implication for the design of isoform-selective inhibitors.
Ji H, Li H, Flinspach M, Poulos TL, Silverman RB.
J Med Chem (2003) 46 : 5700 -5711
PubMed 14667223 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 4.39 5.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL297096 1 5.30
CHEMBL295429 1 4.52
CHEMBL297207 1 4.40
CHEMBL94723 1 4.05
CHEMBL154221 1 4.05
CHEMBL45132 1 4.00
CHEMBL313228 1 -
CHEMBL106815 1 -
CHEMBL43937 1 -
CHEMBL297372 1 -
CHEMBL46913 1 -
CHEMBL524324 1 -
CHEMBL329459 1 -
CHEMBL357485 1 -
CHEMBL346350 1 -
CHEMBL44833 1 -
CHEMBL446171 1 -
CHEMBL154451 1 -
CHEMBL45113 1 -
CHEMBL227937 1 -
CHEMBL433260 1 -
CHEMBL152841 1 -
CHEMBL152645 1 -
CHEMBL1202106 1 -
CHEMBL152583 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL297096 Ki = 5000.0 nM 5.30
CHEMBL295429 Ki = 30000.0 nM 4.52
CHEMBL297207 Ki = 39800.0 nM 4.40
CHEMBL94723 Ki = 90000.0 nM 4.05
CHEMBL154221 Ki = 90000.0 nM 4.05
CHEMBL45132 Ki = 100000.0 nM 4.00
CHEMBL313228 Ki = 411000.0 nM -
CHEMBL106815 Ki = 200000.0 nM -
CHEMBL43937 Ki = 193000.0 nM -
CHEMBL297372 Ki = 105000.0 nM -
CHEMBL46913 Ki = 409000.0 nM -
CHEMBL524324 Ki = 110000.0 nM -
CHEMBL329459 Ki = 150000.0 nM -
CHEMBL357485 Ki = 127900.0 nM -
CHEMBL346350 Ki = 229000.0 nM -
CHEMBL44833 Ki = 245000.0 nM -
CHEMBL446171 Ki = 110000.0 nM -
CHEMBL154451 Ki = 523000.0 nM -
CHEMBL45113 Ki = 414000.0 nM -
CHEMBL227937 Ki = 524000.0 nM -
CHEMBL433260 Ki = 194000.0 nM -
CHEMBL152841 Ki = 226000.0 nM -
CHEMBL152645 Ki = 261000.0 nM -
CHEMBL1202106 Ki = 141000.0 nM -
CHEMBL152583 Ki = 314000.0 nM -