Assay Detail
Binding
CHEMBL679293
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Nitric Oxide Synthase Inhibitory activity tested against recombinant bovine eNOS (Endothelial nitric oxide synthase)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 4.77 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1204422 | — | — | 1 | 5.30 |
| CHEMBL2092928 | — | — | 1 | 4.52 |
| CHEMBL1202117 | — | — | 1 | 4.48 |
| CHEMBL1204426 | — | — | 1 | - |
| CHEMBL1202106 | — | — | 1 | - |
| CHEMBL1204423 | — | — | 1 | - |
| CHEMBL2113674 | — | — | 1 | - |
| CHEMBL1204421 | — | — | 1 | - |
| CHEMBL2092929 | — | — | 1 | - |
| CHEMBL1202118 | — | — | 1 | - |
| CHEMBL1202116 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1204422 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL2092928 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL1202117 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL1204426 | — | Ki | = | 261000.0 | nM | - |
| CHEMBL1202106 | — | Ki | = | 245000.0 | nM | - |
| CHEMBL1204423 | — | Ki | = | 141000.0 | nM | - |
| CHEMBL2113674 | — | Ki | = | 218000.0 | nM | - |
| CHEMBL1204421 | — | Ki | = | 200000.0 | nM | - |
| CHEMBL2092929 | — | Ki | = | 1290000.0 | nM | - |
| CHEMBL1202118 | — | Ki | = | 412000.0 | nM | - |
| CHEMBL1202116 | — | Ki | = | 229000.0 | nM | - |