Assay Detail
Functional
CHEMBL679351
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Antagonistic activity was determined in Human estrogen receptor(hER) of CV-1 cells in cotransfection assay.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.88 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101914 | — | — | 1 | 6.52 |
| CHEMBL101907 | — | — | 1 | 5.98 |
| CHEMBL430855 | — | — | 1 | 5.96 |
| CHEMBL102720 | — | — | 1 | 5.91 |
| CHEMBL103092 | — | — | 1 | 5.84 |
| CHEMBL102754 | — | — | 1 | 5.84 |
| CHEMBL320690 | — | — | 1 | 5.83 |
| CHEMBL318513 | — | — | 1 | 5.81 |
| CHEMBL286595 | — | — | 1 | 5.74 |
| CHEMBL102403 | — | — | 1 | 5.62 |
| CHEMBL317921 | — | — | 1 | 5.58 |
| CHEMBL103232 | — | — | 1 | - |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | - |
| CHEMBL102541 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101914 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL101907 | — | IC50 | = | 1037.0 | nM | 5.98 |
| CHEMBL430855 | — | IC50 | = | 1095.0 | nM | 5.96 |
| CHEMBL102720 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL103092 | — | IC50 | = | 1449.0 | nM | 5.84 |
| CHEMBL102754 | — | IC50 | = | 1449.0 | nM | 5.84 |
| CHEMBL320690 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL318513 | — | IC50 | = | 1537.0 | nM | 5.81 |
| CHEMBL286595 | — | IC50 | = | 1803.0 | nM | 5.74 |
| CHEMBL102403 | — | IC50 | = | 2395.0 | nM | 5.62 |
| CHEMBL317921 | — | IC50 | = | 2632.0 | nM | 5.58 |
| CHEMBL103232 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL103 | PROGESTERONE | IC50 | < | 10000.0 | nM | - |
| CHEMBL102541 | — | IC50 | > | 10000.0 | nM | - |