Assay Detail
Binding
CHEMBL679520
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its ability to inhibit Folyl-poly-gamma-glutamyl synthetase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Folylpolyglutamate synthase, mitochondrial (CHEMBL3171) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Phosphonate and phosphinate analogues of N-acylated gamma-glutamylglutamate. potent inhibitors of glutamate carboxypeptidase II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.23 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306014 | — | — | 1 | 7.70 |
| CHEMBL431954 | — | — | 1 | 6.92 |
| CHEMBL304352 | — | — | 1 | 5.24 |
| CHEMBL307085 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306014 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL431954 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL304352 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL307085 | — | IC50 | = | 8600.0 | nM | 5.07 |