Assay Detail
Binding
CHEMBL679531
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Inhibition of Farnesyl protein transferase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.65 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298734 | LONAFARNIB | 4.0 | 1 | 8.72 |
| CHEMBL66462 | — | — | 1 | 8.41 |
| CHEMBL305798 | — | — | 1 | 7.96 |
| CHEMBL432911 | — | — | 1 | 7.60 |
| CHEMBL305431 | — | — | 1 | 7.30 |
| CHEMBL41934 | — | — | 1 | 7.28 |
| CHEMBL63804 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298734 | LONAFARNIB | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL66462 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL305798 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL432911 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL305431 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL41934 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL63804 | — | IC50 | = | 530.0 | nM | 6.28 |