Assay Detail
Binding
CHEMBL679532
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Inhibition of Farnesyltransferase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.97 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69954 | — | — | 1 | 8.30 |
| CHEMBL306428 | — | — | 1 | 7.37 |
| CHEMBL66699 | — | — | 1 | 6.85 |
| CHEMBL289404 | — | — | 1 | 6.60 |
| CHEMBL67405 | — | — | 1 | 6.42 |
| CHEMBL291576 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69954 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL306428 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL66699 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL289404 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL67405 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL291576 | — | IC50 | = | 500.0 | nM | 6.30 |