Assay Detail
Binding
CHEMBL679584
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Displacement of [3H]gabapentin from alpha2-delta subunit of calcium channel
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of conformationally restricted Gabapentin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.53 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553219 | — | — | 1 | 6.92 |
| CHEMBL940 | GABAPENTIN | 4.0 | 1 | 6.85 |
| CHEMBL542649 | — | — | 1 | 5.82 |
| CHEMBL77879 | — | — | 1 | - |
| CHEMBL538255 | — | — | 1 | - |
| CHEMBL77753 | — | — | 1 | - |
| CHEMBL542655 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553219 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL940 | GABAPENTIN | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL542649 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL77879 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL538255 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL77753 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL542655 | — | IC50 | > | 10000.0 | nM | - |