Assay Detail

CHEMBL679659

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Functional

Inhibition of mammalian Gamma-aminobutyric acid type B receptor (potent agonist)

ChEMBL ↗

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Target

GABA-B receptor (CHEMBL2111463) ↗

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Primary target GABA-B receptor

CHEMBL2111463

Anchored from Assay target.

Protein identity GABA-B receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Confidence	6 — Multiple protein complex / RNA
Curated By	Expert

Target

GABA-B receptor (CHEMBL2111463) ↗

Type	PROTEIN COMPLEX
Organism	Homo sapiens

Publication

The first selective antagonist for a GABAC receptor

Murata Y, Woodward RM, Miledi R, Overman LE
Bioorg Med Chem Lett (1996) 6 : 2073 -2076
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	6.70	6.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL112710	—	—	1	6.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL112710	—	EC50	=	200.0	nM	6.70