Assay Detail
Binding
CHEMBL679699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against farnesyltransferase (FT) using SPA assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Potent inhibitors of protein farnesyltransferase: heteroarenes as cysteine replacements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 8.83 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436440 | — | — | 1 | 9.92 |
| CHEMBL163383 | — | — | 1 | 9.82 |
| CHEMBL159400 | — | — | 1 | 9.70 |
| CHEMBL159764 | — | — | 1 | 9.68 |
| CHEMBL163102 | — | — | 1 | 9.54 |
| CHEMBL433519 | — | — | 1 | 9.54 |
| CHEMBL164480 | — | — | 1 | 9.52 |
| CHEMBL347874 | — | — | 1 | 9.43 |
| CHEMBL274122 | — | — | 1 | 9.40 |
| CHEMBL54044 | — | — | 1 | 9.29 |
| CHEMBL352208 | — | — | 1 | 9.27 |
| CHEMBL159390 | — | — | 1 | 9.24 |
| CHEMBL159324 | — | — | 1 | 9.23 |
| CHEMBL349051 | — | — | 1 | 9.21 |
| CHEMBL350180 | — | — | 1 | 9.20 |
| CHEMBL162868 | — | — | 1 | 9.18 |
| CHEMBL164366 | — | — | 1 | 9.10 |
| CHEMBL163559 | — | — | 1 | 9.09 |
| CHEMBL262187 | — | — | 1 | 9.04 |
| CHEMBL164259 | — | — | 1 | 9.04 |
| CHEMBL164537 | — | — | 1 | 8.85 |
| CHEMBL423459 | — | — | 1 | 8.68 |
| CHEMBL163331 | — | — | 1 | 8.62 |
| CHEMBL350566 | — | — | 1 | 8.57 |
| CHEMBL159326 | — | — | 1 | 8.54 |
| CHEMBL164408 | — | — | 1 | 8.44 |
| CHEMBL348838 | — | — | 1 | 8.33 |
| CHEMBL351869 | — | — | 1 | 7.92 |
| CHEMBL162842 | — | — | 1 | 7.82 |
| CHEMBL159928 | — | — | 1 | 7.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436440 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL163383 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL159400 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL159764 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL163102 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL433519 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL164480 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL347874 | — | IC50 | = | 0.37 | nM | 9.43 |
| CHEMBL274122 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL54044 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL352208 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL159390 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL159324 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL349051 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL350180 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL162868 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL164366 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL163559 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL262187 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL164259 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL164537 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL423459 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL163331 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL350566 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL159326 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL164408 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL348838 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL351869 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL162842 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL159928 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL163270 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL163444 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL161476 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL162959 | — | IC50 | = | 140.0 | nM | 6.85 |