Assay Detail
Functional
CHEMBL679740
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The compound was tested in vitro against the protozoa Entamoeba histolytica, for the inhibition of tubulin polymerization in rat brain
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Entamoeba histolytica |
| Tissue | Brain |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antiparasitic activity of 1H-benzimidazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.95 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69086 | — | — | 1 | 8.30 |
| CHEMBL309135 | — | — | 1 | 8.15 |
| CHEMBL71855 | — | — | 1 | 7.60 |
| CHEMBL69098 | — | — | 1 | 7.41 |
| CHEMBL306226 | BENZIMIDAZOLE | -1.0 | 1 | 7.38 |
| CHEMBL71807 | — | — | 1 | 7.34 |
| CHEMBL71706 | — | — | 1 | 7.26 |
| CHEMBL71905 | — | — | 1 | 7.23 |
| CHEMBL72244 | — | — | 1 | 7.08 |
| CHEMBL303252 | — | — | 1 | 7.02 |
| CHEMBL305513 | — | — | 1 | 6.94 |
| CHEMBL269158 | — | — | 1 | 6.90 |
| CHEMBL70141 | 2-MERCAPTOBENZIMIDAZOLE | — | 1 | 6.88 |
| CHEMBL71936 | — | — | 1 | 6.72 |
| CHEMBL70971 | CARBENDAZIM | 1.0 | 1 | 6.69 |
| CHEMBL71880 | — | — | 1 | 6.46 |
| CHEMBL137 | METRONIDAZOLE | 4.0 | 1 | 6.46 |
| CHEMBL67822 | — | — | 1 | 6.45 |
| CHEMBL72355 | — | — | 1 | 6.41 |
| CHEMBL1483 | ALBENDAZOLE | 4.0 | 1 | 4.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69086 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL309135 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL71855 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL69098 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL306226 | BENZIMIDAZOLE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL71807 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL71706 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL71905 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL72244 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL303252 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL305513 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL269158 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL70141 | 2-MERCAPTOBENZIMIDAZOLE | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL71936 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL70971 | CARBENDAZIM | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL71880 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL137 | METRONIDAZOLE | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL67822 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL72355 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL1483 | ALBENDAZOLE | IC50 | = | 56330.0 | nM | 4.25 |