Assay Detail
Binding
CHEMBL679849
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of dopamine-stimulated adenylate cyclase obtained from rat corpus striatum was determined by the conversion of [32P]ATP to [32P]-cAMP
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as dopamine receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.27 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 9.33 |
| CHEMBL292418 | — | — | 1 | 9.03 |
| CHEMBL303993 | — | — | 1 | 8.18 |
| CHEMBL60706 | — | — | 1 | 7.90 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.10 |
| CHEMBL65397 | — | — | 1 | 6.96 |
| CHEMBL293828 | — | — | 1 | 6.70 |
| CHEMBL299056 | — | — | 1 | 6.69 |
| CHEMBL293158 | — | — | 1 | 6.25 |
| CHEMBL1788322 | — | — | 1 | 5.92 |
| CHEMBL57988 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL292418 | — | Ki | = | 0.94 | nM | 9.03 |
| CHEMBL303993 | — | Ki | = | 6.58 | nM | 8.18 |
| CHEMBL60706 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL65397 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL293828 | — | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL299056 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL293158 | — | Ki | = | 568.0 | nM | 6.25 |
| CHEMBL1788322 | — | Ki | = | 1205.0 | nM | 5.92 |
| CHEMBL57988 | — | Ki | = | 1257.0 | nM | 5.90 |