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Assay Detail

CHEMBL680253

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was evaluated for the inhibition of glycinamide ribonucleotide transformylase obtained from porcine (GAR Tfase)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Trifunctional purine biosynthetic protein adenosine-3 (CHEMBL3972)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of N alpha-(5-deaza-5,6,7,8-tetrahydropteroyl)-L-ornithine.
Singh SK, Singer SC, Ferone R, Waters KA, Mullin RJ, Hynes JB.
J Med Chem (1992) 35 : 2002 -2006
PubMed 1375963 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.32 5.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL289923 1 5.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL289923 IC50 = 4800.0 nM 5.32