Assay Detail
Binding
CHEMBL680328
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Ro-151788 from rat GABA-A receptor alpha-3-beta-2-gamma-2 subunits expressed in HEK293 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Target
GABA A receptor alpha-3/beta-2/gamma-2 (CHEMBL2111343) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Benzodiazepine receptor ligands. 7. Synthesis and pharmacological evaluation of new 3-esters of the 8-chloropyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide. 3-(2-Thienylmethoxycarbonyl) derivative: an anxioselective agent in rodents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.42 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421983 | — | — | 1 | 7.92 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | 7.86 |
| CHEMBL303152 | — | — | 1 | 7.48 |
| CHEMBL911 | ZOLPIDEM | 4.0 | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421983 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL12 | DIAZEPAM | Ki | = | 13.9 | nM | 7.86 |
| CHEMBL303152 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL911 | ZOLPIDEM | Ki | = | 383.0 | nM | 6.42 |