Assay Detail
Binding
CHEMBL680334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibitory activity against gamma-aminobutyric acid aminotransferase from pig brain
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
4-aminobutyrate aminotransferase, mitochondrial (CHEMBL2266) ↗| Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
Publication
Design, synthesis, and biological activity of a difluoro-substituted, conformationally rigid vigabatrin analogue as a potent gamma-aminobutyric acid aminotransferase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 4.51 | 4.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL146927 | CPP-115 FREE BASE | 1.0 | 1 | 4.51 |
| CHEMBL89598 | VIGABATRIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL146927 | CPP-115 FREE BASE | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL89598 | VIGABATRIN | Ki | = | 3200000.0 | nM | - |