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Assay Detail

CHEMBL680339

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]CGP-27492 binding to cat Gamma-aminobutyric acid type B receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Felis catus
Confidence 6 — Multiple protein complex / RNA
Curated By Expert

Target

GABA-B receptor (CHEMBL2111463)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.
Froestl W, Mickel SJ, Hall RG, von Sprecher G, Strub D, Baumann PA, Brugger F, Gentsch C, Jaekel J, Olpe HR.
J Med Chem (1995) 38 : 3297 -3312
PubMed 7650684 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 7.16 7.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL113304 1 7.54
CHEMBL113396 1 6.78

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL113304 IC50 = 29.0 nM 7.54
CHEMBL113396 IC50 = 166.0 nM 6.78