Assay Detail
Functional
CHEMBL680371
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro glycine reuptake inhibitory activity against glycine transporter type-1 isoform C (GlyT-1c) transporter cells after incubation at 30 degrees for 30 min in presence of 50 nM [3H]glycine.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium- and chloride-dependent glycine transporter 1 (CHEMBL4556) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
5,5-Diaryl-2-amino-4-pentenoates as novel, potent, and selective glycine transporter type-2 reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.15 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27850 | — | — | 1 | 5.47 |
| CHEMBL285370 | — | — | 1 | 5.24 |
| CHEMBL28570 | — | — | 1 | 5.19 |
| CHEMBL29220 | — | — | 1 | 5.10 |
| CHEMBL29958 | — | — | 1 | 5.08 |
| CHEMBL29022 | — | — | 1 | 5.05 |
| CHEMBL29256 | — | — | 1 | 5.02 |
| CHEMBL29023 | — | — | 1 | 5.02 |
| CHEMBL283230 | — | — | 1 | - |
| CHEMBL28016 | — | — | 1 | - |
| CHEMBL29279 | — | — | 1 | - |
| CHEMBL287626 | — | — | 1 | - |
| CHEMBL28549 | — | — | 1 | - |
| CHEMBL28577 | — | — | 1 | - |
| CHEMBL1159913 | — | — | 1 | - |
| CHEMBL28746 | — | — | 1 | - |
| CHEMBL29396 | — | — | 1 | - |
| CHEMBL286706 | — | — | 1 | - |
| CHEMBL27914 | — | — | 1 | - |
| CHEMBL418388 | — | — | 1 | - |
| CHEMBL29964 | — | — | 1 | - |
| CHEMBL285592 | — | — | 1 | - |
| CHEMBL281450 | — | — | 1 | - |
| CHEMBL28601 | — | — | 1 | - |
| CHEMBL283017 | — | — | 1 | - |
| CHEMBL416203 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27850 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL285370 | — | IC50 | = | 5770.0 | nM | 5.24 |
| CHEMBL28570 | — | IC50 | = | 6480.0 | nM | 5.19 |
| CHEMBL29220 | — | IC50 | = | 8020.0 | nM | 5.10 |
| CHEMBL29958 | — | IC50 | = | 8340.0 | nM | 5.08 |
| CHEMBL29022 | — | IC50 | = | 8920.0 | nM | 5.05 |
| CHEMBL29256 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL29023 | — | IC50 | = | 9560.0 | nM | 5.02 |
| CHEMBL283230 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL28016 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL29279 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL287626 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL28549 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL28577 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1159913 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL28746 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL29396 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL286706 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27914 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL418388 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL29964 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL285592 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL281450 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL28601 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL283017 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL416203 | — | IC50 | > | 10000.0 | nM | - |