Assay Detail
Binding
CHEMBL680390
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In vitro binding affinity against glycine receptor binding site using [3H]- Glycine as radioligand on rat cortical synaptosomal membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of novel quinoxaline-2,3-dione AMPA/GlyN receptor antagonists: amino acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.38 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293206 | — | — | 1 | 6.43 |
| CHEMBL431382 | — | — | 1 | 6.33 |
| CHEMBL419638 | — | — | 1 | - |
| CHEMBL75761 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293206 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL431382 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL419638 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL75761 | — | IC50 | > | 10000.0 | nM | - |