Assay Detail
Binding
CHEMBL680391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for inhibition of binding of [3H]glycine to specific binding at glycine receptor in rat cortical membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
7-Chloro-4,5-dihydro-8-(1,2,4-triazol-4-yl)-4-oxo-1,2,4-triazolo[1, 5-a]quinoxaline-2- carboxylates as novel highly selective AMPA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.73 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50267 | — | — | 1 | 7.05 |
| CHEMBL310014 | — | — | 1 | 5.66 |
| CHEMBL267276 | TQX-173 | — | 1 | 4.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50267 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL310014 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL267276 | TQX-173 | Ki | = | 33500.0 | nM | 4.47 |