Assay Detail
Binding
CHEMBL680554
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Inhibition of human Glycine Transporter type-2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium- and chloride-dependent glycine transporter 2 (CHEMBL3060) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The first potent and selective inhibitors of the glycine transporter type 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.32 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88588 | — | — | 1 | 7.80 |
| CHEMBL431997 | — | — | 1 | 7.11 |
| CHEMBL92310 | — | — | 1 | 7.08 |
| CHEMBL88573 | — | — | 1 | 6.67 |
| CHEMBL88800 | — | — | 1 | 6.25 |
| CHEMBL91325 | — | — | 1 | 6.16 |
| CHEMBL89493 | — | — | 1 | 5.88 |
| CHEMBL90678 | — | — | 1 | 5.81 |
| CHEMBL89571 | — | — | 1 | 5.64 |
| CHEMBL89867 | — | — | 1 | 5.59 |
| CHEMBL89866 | — | — | 1 | 5.55 |
| CHEMBL91900 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88588 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL431997 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL92310 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL88573 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL88800 | — | IC50 | = | 566.0 | nM | 6.25 |
| CHEMBL91325 | — | IC50 | = | 696.0 | nM | 6.16 |
| CHEMBL89493 | — | IC50 | = | 1321.0 | nM | 5.88 |
| CHEMBL90678 | — | IC50 | = | 1563.0 | nM | 5.81 |
| CHEMBL89571 | — | IC50 | = | 2313.0 | nM | 5.64 |
| CHEMBL89867 | — | IC50 | = | 2563.0 | nM | 5.59 |
| CHEMBL89866 | — | IC50 | = | 2816.0 | nM | 5.55 |
| CHEMBL91900 | — | IC50 | > | 10000.0 | nM | - |