Assay Detail
Binding
CHEMBL680555
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Inhibitory activity against human glycine transporter type 2 (hGlyT2) expressed in Chinese hamster ovary (CHO) cell line
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium- and chloride-dependent glycine transporter 2 (CHEMBL3060) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 6.49 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153717 | — | — | 1 | 7.62 |
| CHEMBL153731 | — | — | 1 | 7.52 |
| CHEMBL358473 | — | — | 1 | 7.48 |
| CHEMBL155273 | — | — | 1 | 7.37 |
| CHEMBL153630 | — | — | 1 | 7.25 |
| CHEMBL150560 | — | — | 1 | 7.24 |
| CHEMBL150377 | — | — | 1 | 7.17 |
| CHEMBL348200 | — | — | 1 | 7.11 |
| CHEMBL153075 | — | — | 1 | 7.09 |
| CHEMBL153139 | — | — | 1 | 7.07 |
| CHEMBL357936 | — | — | 1 | 7.05 |
| CHEMBL153410 | — | — | 1 | 7.00 |
| CHEMBL348211 | — | — | 1 | 6.92 |
| CHEMBL149571 | — | — | 1 | 6.89 |
| CHEMBL150901 | — | — | 1 | 6.89 |
| CHEMBL150796 | — | — | 1 | 6.89 |
| CHEMBL150954 | — | — | 1 | 6.85 |
| CHEMBL153148 | — | — | 1 | 6.85 |
| CHEMBL153331 | — | — | 1 | 6.77 |
| CHEMBL433739 | — | — | 1 | 6.52 |
| CHEMBL150522 | — | — | 1 | 6.50 |
| CHEMBL153521 | — | — | 1 | 6.48 |
| CHEMBL150505 | — | — | 1 | 6.43 |
| CHEMBL150836 | — | — | 1 | 6.17 |
| CHEMBL356187 | — | — | 1 | 5.96 |
| CHEMBL153591 | — | — | 1 | 5.92 |
| CHEMBL153154 | — | — | 1 | 5.92 |
| CHEMBL2112891 | — | — | 1 | 5.85 |
| CHEMBL150972 | — | — | 1 | 5.80 |
| CHEMBL153680 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153717 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL153731 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL358473 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL155273 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL153630 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL150560 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL150377 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL348200 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL153075 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL153139 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL357936 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL153410 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL348211 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL150796 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL149571 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL150901 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL150954 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL153148 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL153331 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL433739 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL150522 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL153521 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL150505 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL150836 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL356187 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL153591 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL153154 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2112891 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL150972 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL153680 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL152937 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL153296 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL150409 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL153355 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL152979 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL150502 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL421793 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL149515 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL150786 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL153124 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL151644 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL153670 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL348213 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL153151 | — | IC50 | ~ | 10000.0 | nM | - |
| CHEMBL150722 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL155222 | — | IC50 | > | 5000.0 | nM | - |