Assay Detail
Binding
CHEMBL680916
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Concentration required for the neuroprotective effect determined by inhibition of GCP II
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.55 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47009 | — | — | 1 | 9.21 |
| CHEMBL64901 | — | — | 1 | 8.02 |
| CHEMBL303352 | — | — | 1 | 7.89 |
| CHEMBL65043 | — | — | 1 | 6.66 |
| CHEMBL433298 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47009 | — | EC50 | = | 0.62 | nM | 9.21 |
| CHEMBL64901 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL303352 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL65043 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL433298 | — | EC50 | = | 1100.0 | nM | 5.96 |