Assay Detail
Binding
CHEMBL680923
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Inhibitory activity against expressed rat Glutamate carboxypeptidase II, using a substrate concentration of 5 uM
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.52 | 8.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47009 | — | — | 1 | 8.29 |
| CHEMBL103512 | — | — | 1 | 8.16 |
| CHEMBL103725 | — | — | 1 | 7.66 |
| CHEMBL322896 | — | — | 1 | 7.54 |
| CHEMBL46005 | — | — | 1 | 7.33 |
| CHEMBL318315 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47009 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL103512 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL103725 | — | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL322896 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL46005 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL318315 | — | IC50 | = | 750.0 | nM | 6.12 |